Brill Zachary G, Condakes Matthew L, Ting Chi P, Maimone Thomas J
Department of Chemistry, University of California, Berkeley , Berkeley, California 94720, United States.
Chem Rev. 2017 Sep 27;117(18):11753-11795. doi: 10.1021/acs.chemrev.6b00834. Epub 2017 Mar 15.
The pool of abundant chiral terpene building blocks (i.e., "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex natural products, including many terpenes themselves. As inexpensive and versatile starting materials, such compounds continue to influence modern synthetic chemistry. This review highlights 21st century terpene total syntheses which themselves use small, terpene-derived materials as building blocks. An outlook to the future of research in this area is highlighted as well.
大量手性萜类结构单元（即“手性池萜类”）长期以来一直是复杂天然产物化学合成的起点，其中包括许多萜类本身。作为廉价且通用的起始原料，这类化合物持续影响着现代合成化学。本综述重点介绍了21世纪的萜类全合成，这些合成本身使用小的、源自萜类的材料作为结构单元。同时也强调了该领域未来研究的展望。
