根据出生时的孕周划分的与早产相关的风险因素。

Risk factors associated with preterm birth according to gestational age at birth.

作者信息

Ofori Benjamin D, Le Tiec Magali, Bérard Anick

机构信息

Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada.

出版信息

Pharmacoepidemiol Drug Saf. 2008 Jun;17(6):556-64. doi: 10.1002/pds.1575.

DOI:10.1002/pds.1575

PMID:18327870

Abstract

PURPOSE

To identify and quantify risk factors associated with preterm birth, stratified by gestational age at birth.

METHODS

Three case-control analyses were done. Controls were pregnancies of > or =37 weeks of gestational age at birth. Cases were defined as: <28, 28-32, 33- <37 weeks of gestational age at birth respectively in the three case-control analyses. Women were categorized according to whether they carried single or multiple infants.

RESULTS

Obstetrical conditions (placenta previa, placental abruption), and maternal hypertension were significantly associated with preterm delivery in all case-control analyses (adjusted OR between 1.34-19.56, p < 0.05). Leading risk factors for preterm delivery in singleton pregnancies were placental abruption and placenta previa (adjusted ORs 4.85 and 4.13, p < 0.05). For multiple pregnancies they were polyhydramnios and maternal hypertension (adjusted ORs 4.39 and 2.45, p < 0.05).

CONCLUSIONS

Obstetrical conditions during the pregnancy and maternal hypertension are important risk factors for preterm birth.

摘要

目的

识别并量化与早产相关的风险因素，并按出生时的孕周进行分层。

方法

进行了三项病例对照分析。对照组为出生时孕周≥37周的妊娠。在三项病例对照分析中，病例分别定义为：出生时孕周<28周、28 - 32周、33 - <37周。根据妇女所怀单胎或多胎进行分类。

结果

在所有病例对照分析中，产科情况（前置胎盘、胎盘早剥）以及母亲高血压与早产显著相关（校正比值比在1.34 - 19.56之间，p < 0.05）。单胎妊娠早产的主要风险因素是胎盘早剥和前置胎盘（校正比值比分别为4.85和4.13，p < 0.05）。对于多胎妊娠，主要风险因素是羊水过多和母亲高血压（校正比值比分别为4.39和2.45，p < 0.05）。