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[适应的酶促化学机制]

[The enzymatic chemical mechanisms of adaptation].

作者信息

Grigorian M S, Tatevosian L G

出版信息

Zh Evol Biokhim Fiziol. 1991 Jan-Feb;27(1):7-12.

PMID:1832807
Abstract

In sheep from biogeochemical provinces enriched by molybdenum and copper and in a model form of molybdenum toxicosis in animals, the important role of enzymic and neurohumoral systems in the development of adaptation to excessive uptake of molybdenum and copper has been demonstrated. Adaptive reorganization of the activity of enzymic systems (xanthine oxidase, ceruloplasmin, succinate dehydrogenase, aspartate and alanine aminotransferases) and gradual involvement of neurohumoral mechanisms of the sympathoadrenal and cholinoreactive systems provide for adaptation of some animals in molybdenum and copper-molybdenum biogeochemical provinces. In other sheep, under the same conditions, dystonic disturbances in the vegetative nervous systems are observed together with the development of molybdenum toxicosis.

摘要

在来自钼和铜富集的生物地球化学省的绵羊以及动物钼中毒的模型形式中,酶系统和神经体液系统在适应过量摄取钼和铜的过程中所起的重要作用已得到证实。酶系统(黄嘌呤氧化酶、铜蓝蛋白、琥珀酸脱氢酶、天冬氨酸和丙氨酸转氨酶)活性的适应性重组以及交感肾上腺和胆碱反应系统神经体液机制的逐渐参与,使一些动物能够适应钼和钼 - 铜生物地球化学省的环境。在其他绵羊中,在相同条件下,随着钼中毒的发展,会观察到植物神经系统的张力障碍性紊乱。

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