Cerqueira F, Cidade H, van Ufford L, Beukelman C, Kijjoa A, Nascimento M S J
Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto, Faculdade de Farmácia, Porto, Portugal.
Int Immunopharmacol. 2008 Apr;8(4):597-602. doi: 10.1016/j.intimp.2007.12.013. Epub 2008 Jan 15.
Artelastin, a prenylated flavone previously isolated from Artocarpus elasticus, was evaluated for its effect on the production of reactive oxygen species (ROS) by human polymorphonuclear neutrophils (PMNs) and nitric oxide (NO) by J774 murine macrophage cell line. Artelastin showed to be an inhibitor of ROS production due to a strong O2- scavenging activity. No effect was observed on the activity of myeloperoxidase (MPO). Artelastin showed also to be an inhibitor of NO production without NO scavenging activity. This flavone seems to interfere with the expression of the inducible nitric oxide synthase (iNOS) immediately after LPS-IFNgamma-macrophage stimulation.
Artelastin是一种先前从面包树中分离得到的异戊烯基化黄酮，我们评估了它对人多形核中性粒细胞（PMN）产生活性氧（ROS）以及J774鼠巨噬细胞系产生一氧化氮（NO）的影响。由于具有强大的超氧阴离子清除活性，Artelastin表现为ROS产生的抑制剂。未观察到对髓过氧化物酶（MPO）活性有影响。Artelastin还表现为NO产生的抑制剂，且没有NO清除活性。这种黄酮似乎在脂多糖-γ干扰素-巨噬细胞刺激后立即干扰诱导型一氧化氮合酶（iNOS）的表达。
