Lott Jason P, Werth Victoria P, Kovarik Carrie L
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
J Am Acad Dermatol. 2008 Jul;59(1):139-42. doi: 10.1016/j.jaad.2008.01.023. Epub 2008 Mar 6.
Cutaneous Mycobacterium haemophilum infections are most often the result of HIV or transplantation-associated immunosuppression. Rarely, M. haemophilum may infect healthy patients or iatrogenically immunosuppressed patients without transplantation. We herein report two cases of cutaneous M. haemophilum infection in HIV-negative patients without transplantation undergoing iatrogenic immunosuppression. Our cases and a literature review highlight the various clinical contexts in which M. haemophilum may arise in this patient population. Accordingly, we emphasize that a high index of suspicion is needed for diagnosis, which ultimately relies on skin biopsy, histopathologic examination, and culture.
皮肤嗜血性分枝杆菌感染通常是由HIV或移植相关免疫抑制引起的。罕见情况下，嗜血性分枝杆菌可能感染健康患者或未进行移植的医源性免疫抑制患者。我们在此报告两例未进行移植但接受医源性免疫抑制的HIV阴性患者发生皮肤嗜血性分枝杆菌感染的病例。我们的病例及文献综述强调了该患者群体中嗜血性分枝杆菌可能出现的各种临床情况。因此，我们强调诊断需要高度怀疑，最终诊断依赖于皮肤活检、组织病理学检查和培养。
