Miyawaki Masakazu, Okutani Takahiro, Higuchi Ryuzo, Yoshikawa Norishige
Division of Perinatal Medicine, NICU, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-8509, Japan.
Early Hum Dev. 2008 Jun;84(6):375-9. doi: 10.1016/j.earlhumdev.2007.10.005. Epub 2008 Mar 7.
Angiotensin II (AII) has been reported to play an important role in organ fibrosis, and a local renin-angiotensin-system (RAS) has been demonstrated in the lungs. However, the relationship of the RAS to chronic lung disease of the newborn (CLD) remains obscure.
To investigate the plasma AII levels throughout the neonatal period in very low-birth weight (VLBW) infants and examine the possible factors that might affect the AII levels.
The study includes 20 VLBW infants. Blood samples were collected on days 0, 7, 21 and 35 and plasma AII levels were assayed using an enzyme immunoassay. The data were analyzed by a multiple linear regression analysis with the plasma AII level as the dependent variable and significant factors determined based on a univariate analysis as independent variables.
The geometric mean of the plasma AII concentrations on days 0, 7, 21 and 35 was 51 pg/mL, 86 pg/mL, 132 pg/mL, and 50 pg/mL, respectively. On day 21, only CLD (p<0.01) had a highly significant association with the plasma AII level. On day 35, birth weight (p<0.05) and CLD (p<0.01) had a highly significant association with the plasma AII level. This analysis confirmed CLD to be the most significant factor associated with plasma AII level on days 21 and 35.
These findings suggest that higher levels of plasma AII in VLBW infants appear to be related to the development of CLD.
据报道，血管紧张素II（AII）在器官纤维化中起重要作用，并且已在肺中证实存在局部肾素-血管紧张素系统（RAS）。然而，RAS与新生儿慢性肺病（CLD）之间的关系仍不清楚。
研究极低出生体重（VLBW）婴儿整个新生儿期的血浆AII水平，并检查可能影响AII水平的因素。
该研究包括20名VLBW婴儿。在第0、7、21和35天采集血样，并使用酶免疫测定法测定血浆AII水平。以血浆AII水平为因变量，根据单变量分析确定的显著因素为自变量，通过多元线性回归分析对数据进行分析。
第0、7、21和35天血浆AII浓度的几何平均值分别为51 pg/mL、86 pg/mL、132 pg/mL和50 pg/mL。在第21天，只有CLD（p<0.01）与血浆AII水平有高度显著相关性。在第35天，出生体重（p<0.05）和CLD（p<0.01）与血浆AII水平有高度显著相关性。该分析证实CLD是第21天和第35天与血浆AII水平相关的最显著因素。
这些发现表明，VLBW婴儿血浆AII水平升高似乎与CLD的发生有关。
