Goldstein Richard A
Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
Curr Opin Struct Biol. 2008 Apr;18(2):170-7. doi: 10.1016/j.sbi.2008.01.006. Epub 2008 Mar 6.
The observed distribution of protein structures can give us important clues about the underlying evolutionary process, imposing important constraints on possible models. The availability of results from an increasing number of genome projects has made the development of these models an active area of research. Models explaining the observed distribution of structures have focused on the inherent functional capabilities and structural properties of different folds and on the evolutionary dynamics. Increasingly, these elements are being combined.
观察到的蛋白质结构分布能为我们提供有关潜在进化过程的重要线索，对可能的模型施加重要限制。越来越多基因组项目的结果可用性使得这些模型的开发成为一个活跃的研究领域。解释观察到的结构分布的模型聚焦于不同折叠的固有功能能力和结构特性以及进化动力学。这些要素越来越多地被结合起来。
