Oren Hale, Yilmaz Sebnem, Sercan Zeynep, Demircioğlu Fatih, Yüksel Erdinç, Irken Gülersu
Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, 35340 Balçova, Izmir, Turkey.
Cancer Genet Cytogenet. 2008 Apr 1;182(1):43-5. doi: 10.1016/j.cancergencyto.2007.12.006.
Additional chromosomal abnormalities are found in 5-20% of patients during chronic phase of chronic myeloid leukemia and in 60-80% preceding or accompanying blast crisis. These abnormalities are important in disease progression and, because they may occur before hematological and clinical symptoms, can be taken as a prognostic indicator. An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in bone marrow examinations and then developed isolated myelosarcoma 1 year after onset, with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36).
