Luk'ianova A S, Pien'kovs'ka-Hrelia B, Masliak Z V
Tsitol Genet. 2009 May-Jun;43(3):48-54.
In this article is presented a case of multiple chromosomal aberrations in a patient with CML accelerated phase. Cytogenetic and molecular cytogenetic studies allowed us to determine the presence of t(9;22)(q34;q11) and to identify additional abnormalities such as t(1;2)(p36;p21), del (6)(q21), +del(8)(q22), del(18)(q21), +der (22), some of which are not typical for this kind of neoplasia. This case is compared with publications of the same cases. Our data suggested that detected changes can be correlated with previous treatment regimens and the influence of these changes on progression of disease is discussed.
本文介绍了一例慢性粒细胞白血病加速期患者的多种染色体畸变情况。细胞遗传学和分子细胞遗传学研究使我们能够确定t(9;22)(q34;q11)的存在，并识别出其他异常，如t(1;2)(p36;p21)、del(6)(q21)、+del(8)(q22)、del(18)(q21)、+der(22)，其中一些异常在这类肿瘤中并不常见。将该病例与相同病例的文献进行了比较。我们的数据表明，检测到的变化可能与先前的治疗方案相关，并讨论了这些变化对疾病进展的影响。
