Cao Shuqin, Fu Xinjian, Wang Ningxia, Wang Hong, Yang Yajiang
Department of Chemistry, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, China.
Int J Pharm. 2008 Jun 5;357(1-2):95-9. doi: 10.1016/j.ijpharm.2008.01.054. Epub 2008 Feb 6.
Supramolecular hydrogels were prepared from l-phenylalanine derivatives as novel hydrogelators. Salicylic acid (SA), acting as a model drug, was entrapped in the supramolecular hydrogels. The release behavior of SA molecules in the supramolecular hydrogels was investigated by using UV-vis spectroscopy. The influence of the concentration of the hydrogelator, pH values of the accepting media, the temperature, and the concentration of SA on the release behavior of SA was investigated under static conditions. The results indicated that the release rate of SA in the supramolecular hydrogels was slightly retarded with an increase of the hydrogelator concentration. Also, the release rates of SA increased with an increase of temperature and with the SA content. Furthermore, the release behavior of SA was found to be different at various pH values in buffers as accepting media. The study of the release kinetics indicated that the release behavior of SA was in accord with the Higuchi equation and the diffusion-controlled mechanism involved in the Fickian model.
以L-苯丙氨酸衍生物作为新型水凝胶剂制备了超分子水凝胶。作为模型药物的水杨酸（SA）被包裹在超分子水凝胶中。通过紫外可见光谱研究了SA分子在超分子水凝胶中的释放行为。在静态条件下，研究了水凝胶剂浓度、接受介质的pH值、温度以及SA浓度对SA释放行为的影响。结果表明，随着水凝胶剂浓度的增加，SA在超分子水凝胶中的释放速率略有减慢。此外，SA的释放速率随温度升高和SA含量增加而增加。此外，发现SA在作为接受介质的缓冲液中不同pH值下的释放行为不同。释放动力学研究表明，SA的释放行为符合Higuchi方程和菲克模型中涉及的扩散控制机制。
