• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

包裹在生物水凝胶中的非离子表面活性剂囊泡用于可调节地递送植物抗毒素白藜芦醇。

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol.

作者信息

Machado Noelia D, Fernández Mariana A, Häring Marleen, Saldías César, Díaz David Díaz

机构信息

Instituto de Investigaciones en Físico-Química de Córdoba (INFIQC-CONICET), Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria X5000HUA Córdoba Argentina.

Institute of Organic Chemistry, University of Regensburg Universitätstrasse. 31 93040 Regensburg Germany

出版信息

RSC Adv. 2019 Mar 8;9(14):7601-7609. doi: 10.1039/c8ra09655d. eCollection 2019 Mar 6.

DOI:10.1039/c8ra09655d
PMID:35521173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061210/
Abstract

A series of biohydrogels based on mixtures of kappa-carrageenan (κ-carrageenan, κ-C) and gelatin were evaluated as potential soft delivery vehicles for the encapsulation and subsequent release of non-ionic surfactant vesicles (niosomes) loaded with resveratrol (RSV). The niosomes were prepared using a mixture of amphiphilic lipids Tween 80 and Span 80 in water. The results showed that RSV-niosomes did not significantly affect the hydrogelation properties of the biopolymer mixture. Moreover, drug release experiments from biohydrogels containing RSV-niosomes were successfully carried out under simulated gastrointestinal conditions. The RSV-niosomal liberation profiles from hydrogels were fitted using first order kinetics, Higuchi, Korsmeyer-Peppas and Weibull drug release models, showing the prevalence of diffusion mechanisms in each case. In addition, the RSV release was easily tuned by adjusting the total concentration of κ-C : gelatin. Interestingly, the niosomal-hydrogel system was also found to prevent the -to- photoisomerization of RSV.

摘要

评估了一系列基于κ-卡拉胶（κ-C）和明胶混合物的生物水凝胶，作为包裹负载白藜芦醇（RSV）的非离子表面活性剂囊泡（niosomes）并随后释放的潜在软递送载体。使用两亲性脂质吐温80和司盘80在水中的混合物制备niosomes。结果表明，RSV-niosomes对生物聚合物混合物的水凝胶化性质没有显著影响。此外，在模拟胃肠道条件下成功进行了含RSV-niosomes的生物水凝胶的药物释放实验。水凝胶中RSV-niosomal的释放曲线采用一级动力学、Higuchi、Korsmeyer-Peppas和Weibull药物释放模型拟合，表明每种情况下扩散机制占主导。此外，通过调整κ-C与明胶的总浓度可以轻松调节RSV的释放。有趣的是，还发现niosomal-水凝胶系统可防止RSV的顺反异构化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/e75d84d10084/c8ra09655d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/d2f5af406567/c8ra09655d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/ce3e0c4be5eb/c8ra09655d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/a4a3a8e25bd9/c8ra09655d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/51a58445e52f/c8ra09655d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/1215a2d220a8/c8ra09655d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/a65195ffc5d9/c8ra09655d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/e75d84d10084/c8ra09655d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/d2f5af406567/c8ra09655d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/ce3e0c4be5eb/c8ra09655d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/a4a3a8e25bd9/c8ra09655d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/51a58445e52f/c8ra09655d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/1215a2d220a8/c8ra09655d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/a65195ffc5d9/c8ra09655d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b985/9061210/e75d84d10084/c8ra09655d-f7.jpg

相似文献

1
Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol.包裹在生物水凝胶中的非离子表面活性剂囊泡用于可调节地递送植物抗毒素白藜芦醇。
RSC Adv. 2019 Mar 8;9(14):7601-7609. doi: 10.1039/c8ra09655d. eCollection 2019 Mar 6.
2
Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids.基于多糖的水凝胶中的阳离子纳米复合物作为递送核酸的多功能可生物降解杂化材料。
J Mater Chem B. 2017 Oct 7;5(37):7756-7767. doi: 10.1039/c7tb01691c. Epub 2017 Sep 18.
3
Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes.通过包封于非离子表面活性剂泡囊中来保存白藜芦醇的抗氧化能力。
Foods. 2021 Apr 30;10(5):988. doi: 10.3390/foods10050988.
4
Effect of different types of surfactants on the physical properties and stability of carvedilol nano-niosomes.不同类型表面活性剂对卡维地洛纳米囊泡物理性质及稳定性的影响
Adv Biomed Res. 2016 Mar 16;5:48. doi: 10.4103/2277-9175.178781. eCollection 2016.
5
Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s).基于奈米脂质体的白藜芦醇水凝胶用于局部应用：一种治疗与疼痛相关疾病的有效方法。
Biomed Pharmacother. 2017 Apr;88:480-487. doi: 10.1016/j.biopha.2017.01.083. Epub 2017 Jan 23.
6
Development of Niosomal Vesicles Loaded Mometasone Furoate Gel for Transdermal Delivery and its Evaluation.载莫米松糠酸酯脂质体凝胶的经皮给药系统的研制及其评价。
Recent Adv Drug Deliv Formul. 2023;17(4):300-313. doi: 10.2174/0126673878259437231031114907.
7
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus.新型辛伐他汀纳米囊泡凝胶的优化、理化特性表征及其对大肠杆菌和金黄色葡萄球菌的抗菌活性。
Chem Phys Lipids. 2021 Jan;234:105019. doi: 10.1016/j.chemphyslip.2020.105019. Epub 2020 Nov 21.
8
Release Studies on Ciprofloxacin Loaded Non-ionic Surfactant Vesicles.环丙沙星负载非离子表面活性剂囊泡的释放研究
Avicenna J Med Biotechnol. 2015 Apr-Jun;7(2):69-75.
9
Synergistic effect of curcumin-Cu and curcumin-Ag nanoparticle loaded niosome: Enhanced antibacterial and anti-biofilm activities.姜黄素-Cu 和姜黄素-Ag 纳米载药囊泡的协同作用：增强抗菌和抗生物膜活性。
Bioorg Chem. 2021 Oct;115:105116. doi: 10.1016/j.bioorg.2021.105116. Epub 2021 Jun 24.
10
Formulation and Characterization of a 3D-Printed Cryptotanshinone-Loaded Niosomal Hydrogel for Topical Therapy of Acne.3D 打印 cryptotanshinone 负载的尼泊金酯类脂囊泡水凝胶的配方与表征及其在痤疮局部治疗中的应用。
AAPS PharmSciTech. 2020 May 31;21(5):159. doi: 10.1208/s12249-020-01677-1.

引用本文的文献

1
Resveratrol-A Promising Therapeutic Agent with Problematic Properties.白藜芦醇-A：一种具有问题特性的有前景的治疗剂。
Pharmaceutics. 2025 Jan 19;17(1):134. doi: 10.3390/pharmaceutics17010134.
2
Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds.海洋来源的多糖水凝胶作为天然生物活性化合物的递送平台
Int J Mol Sci. 2025 Jan 17;26(2):764. doi: 10.3390/ijms26020764.
3
Niosome-loaded Tet-Amp against S. aureus, K. pneumoniae, and P. aeruginosa.负载奈米囊泡的四环素-氨苄西林对金黄色葡萄球菌、肺炎克雷伯菌和铜绿假单胞菌的作用。

本文引用的文献

1
Cyclodextrin modified niosomes to encapsulate hydrophilic compounds.环糊精修饰的非离子表面活性剂囊泡用于包封亲水性化合物。
RSC Adv. 2018 Aug 23;8(52):29909-29916. doi: 10.1039/c8ra05021j. eCollection 2018 Aug 20.
2
Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids.基于多糖的水凝胶中的阳离子纳米复合物作为递送核酸的多功能可生物降解杂化材料。
J Mater Chem B. 2017 Oct 7;5(37):7756-7767. doi: 10.1039/c7tb01691c. Epub 2017 Sep 18.
3
Injectable biodegradable hydrogels: progress and challenges.
Braz J Microbiol. 2024 Dec;55(4):3563-3589. doi: 10.1007/s42770-024-01516-6. Epub 2024 Oct 23.
4
Preparation and optimization of niosome encapsulated meropenem for significant antibacterial and anti-biofilm activity against methicillin-resistant isolates.用于对耐甲氧西林分离株具有显著抗菌和抗生物膜活性的尼莫司囊泡包封美罗培南的制备与优化
Heliyon. 2024 Aug 6;10(16):e35651. doi: 10.1016/j.heliyon.2024.e35651. eCollection 2024 Aug 30.
5
Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability.载多西环素脂质体凝胶的透皮给药系统：旨在提高多西环素稳定性
ACS Omega. 2024 Jul 23;9(31):33542-33556. doi: 10.1021/acsomega.4c01224. eCollection 2024 Aug 6.
6
Thermo-Responsive Hydrogels Encapsulating Targeted Core-Shell Nanoparticles as Injectable Drug Delivery Systems.包封靶向核壳纳米颗粒的热响应水凝胶作为可注射药物递送系统
Pharmaceutics. 2023 Sep 21;15(9):2358. doi: 10.3390/pharmaceutics15092358.
7
Mechanistic insights into encapsulation and release of drugs in colloidal niosomal systems: biophysical aspects.胶体非离子表面活性剂囊泡系统中药物包封与释放的机制洞察：生物物理方面
RSC Adv. 2021 Oct 29;11(56):35110-35126. doi: 10.1039/d1ra06057k. eCollection 2021 Oct 28.
8
Effects of Imipenem-containing Niosome nanoparticles against high prevalence methicillin-resistant Staphylococcus Epidermidis biofilm formed.含亚胺培南的尼森体纳米粒对高流行率耐甲氧西林表皮葡萄球菌生物膜形成的影响。
Sci Rep. 2022 Mar 24;12(1):5140. doi: 10.1038/s41598-022-09195-9.
9
Enhanced Antibacterial Activity of Extract against Multidrug-Resistant through Niosome Encapsulation.通过脂质体包封增强提取物对多重耐药菌的抗菌活性。
Nanomaterials (Basel). 2021 Jun 15;11(6):1573. doi: 10.3390/nano11061573.
10
Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes.通过包封于非离子表面活性剂泡囊中来保存白藜芦醇的抗氧化能力。
Foods. 2021 Apr 30;10(5):988. doi: 10.3390/foods10050988.
可注射生物可降解水凝胶：进展与挑战
J Mater Chem B. 2013 Oct 28;1(40):5371-5388. doi: 10.1039/c3tb20940g. Epub 2013 Aug 23.
4
Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials.白藜芦醇与阿尔茨海默病。从分子病理生理学到临床试验。
Exp Gerontol. 2018 Nov;113:36-47. doi: 10.1016/j.exger.2018.09.019. Epub 2018 Sep 25.
5
Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair.新型多药物递送水凝胶利用瘢痕归巢脂质体改善脊髓损伤修复。
Theranostics. 2018 Aug 7;8(16):4429-4446. doi: 10.7150/thno.26717. eCollection 2018.
6
Nanoencapsulation techniques for compounds and products with antioxidant and antimicrobial activity - A critical view.纳米封装技术在具有抗氧化和抗菌活性的化合物和产品中的应用——批判性观点。
Eur J Med Chem. 2018 Sep 5;157:1326-1345. doi: 10.1016/j.ejmech.2018.08.076. Epub 2018 Aug 30.
7
Release of small bioactive molecules from physical gels.物理凝胶中小分子生物活性物质的释放。
Chem Soc Rev. 2018 Feb 21;47(4):1484-1515. doi: 10.1039/c7cs00515f. Epub 2018 Jan 22.
8
Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery.具有嵌入式脂质体的粘弹性藻酸盐糊剂用于局部口腔药物递送。
Int J Biol Macromol. 2018 May;111:62-69. doi: 10.1016/j.ijbiomac.2017.12.137. Epub 2017 Dec 29.
9
Production of pectin-whey protein nano-complexes as carriers of orange peel oil.生产果胶-乳清蛋白纳米复合物作为陈皮油的载体。
Carbohydr Polym. 2017 Dec 1;177:369-377. doi: 10.1016/j.carbpol.2017.09.009. Epub 2017 Sep 6.
10
Development of a nutraceutical nano-delivery system through emulsification/internal gelation of alginate.通过海藻酸钠的乳化/内凝胶化开发营养纳米递药系统。
Food Chem. 2017 Aug 15;229:286-295. doi: 10.1016/j.foodchem.2017.02.071. Epub 2017 Feb 16.