Suda Toshio, Arai Fumio
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
Cell. 2008 Mar 7;132(5):729-30. doi: 10.1016/j.cell.2008.02.017.
There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/beta-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.
人们对了解骨髓微环境中使造血干细胞（HSC）保持静止状态的信号非常感兴趣。在本期《细胞干细胞》杂志中，弗莱明等人（2008年）报告称，阻断微环境中的Wnt信号会增加增殖性造血干细胞的数量，并降低它们重建受辐照受体小鼠造血系统的能力。这些发现表明，Wnt/β-连环蛋白活性对于维持骨髓微环境中造血干细胞的静止状态至关重要。
