造血干细胞及其微环境。

Hematopoietic stem cells and their niche.

作者信息

Suda Toshio, Arai Fumio, Hirao Atsushi

机构信息

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

出版信息

Trends Immunol. 2005 Aug;26(8):426-33. doi: 10.1016/j.it.2005.06.006.

DOI:10.1016/j.it.2005.06.006

PMID:15979407

Abstract

Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.

摘要

最近的证据表明，成骨细胞是成年骨髓（BM）中造血干细胞（HSC）特定微环境或生态位的关键组成部分。干细胞在骨髓中以未成熟状态持续存在。造血干细胞的静止状态由受体-配体信号和细胞粘附分子动态控制。在这篇综述中，讨论了生态位中造血干细胞的特征。对正常干细胞与癌症干细胞及其生态位之间关系的理解应该会带来针对再生医学和癌症治疗的新策略的发展。