Rombaux P, Guérit J-M, Mouraux A
Department of Otorhinolaryngology, université catholique de Louvain, cliniques universitaires Saint-Luc, 10, avenue Hippocrate, 1200 Brussels, Belgium.
Neurophysiol Clin. 2008 Feb;38(1):23-30. doi: 10.1016/j.neucli.2007.12.002. Epub 2008 Jan 22.
To determine whether or not chemosensory event-related brain potentials (CSERP) elicited by nociceptive unilateral intranasal (CO2) trigeminal stimulation are lateralized and, if they are, whether this hemispheric lateralization is related to the side of the stimulated nostril.
Nine healthy right-handed subjects participated to the study. CSERPs were recorded after left or right monorhinal CO2 stimulation. Latency and baseline-to-peak amplitude of each CSERP component were compared across stimulation conditions (left and right nostril), scalp locations (lower-frontal, frontal, mid-temporal, central, posterior-temporal, parietal) and hemispheres (left or right), using a three-factor analysis of variance (ANOVA) for repeated measures.
Intranasal trigeminal CO2 stimulation elicited a large N400-P550 complex. This complex was preceded by an earlier N300 component. Whatever the stimulated nostril, N300, N400 and P550 amplitudes were significantly higher on the right as compared to the left hemisphere, at lower-frontal recording sites. The side of chemosensory stimulation (left or right nostril) did not significantly affect CSERP components.
This study showed that in healthy right-handed volunteers with normal olfactory ability, intranasal chemosensory trigeminal stimulation may elicit a series of event-related brain potentials, which all display a significant right-hemisphere predominance, irrespective of the stimulated nostril. The observed lateralization was maximal at lower-frontal recording sites.
确定由伤害性单侧鼻内（二氧化碳）三叉神经刺激引发的化学感觉事件相关脑电位（CSERP）是否存在偏侧化，如果存在，这种半球偏侧化是否与受刺激鼻孔的一侧有关。
九名健康的右利手受试者参与了该研究。在单侧左鼻孔或右鼻孔二氧化碳刺激后记录CSERP。使用重复测量的三因素方差分析（ANOVA），比较每个CSERP成分在不同刺激条件（左鼻孔和右鼻孔）、头皮位置（额下部、额部、颞中部、中央、颞后部、顶叶）和半球（左半球或右半球）下的潜伏期和基线到峰值的振幅。
鼻内三叉神经二氧化碳刺激引发了一个大的N400 - P550复合波。该复合波之前有一个更早的N300成分。无论受刺激的鼻孔是哪一侧，在额下部记录部位，右半球的N300、N400和P550振幅均显著高于左半球。化学感觉刺激的一侧（左鼻孔或右鼻孔）对CSERP成分没有显著影响。
本研究表明，在嗅觉能力正常的健康右利手志愿者中，鼻内化学感觉三叉神经刺激可能引发一系列事件相关脑电位，无论受刺激的鼻孔是哪一侧，这些脑电位均显示出显著的右半球优势。观察到的偏侧化在额下部记录部位最为明显。
