Howe Peter W A
Analytical Sciences, Syngenta Limited, Jealott's Hill Research Centre, Bracknell, Berkshire, RG42 6EY, UK.
J Magn Reson. 2008 Jun;192(2):177-82. doi: 10.1016/j.jmr.2008.02.013. Epub 2008 Feb 16.
The use of adiabatic 180 degrees X-pulses within INEPT refocusing periods results in chemical shift-dependent evolution of J-couplings. This has been viewed as a disadvantage and several methods of overcoming it have been suggested. This article shows that there is the potential to use this chemical shift dependence to determine heteronuclear chemical shift without a heteronuclear evolution time. In this way, it possible to estimate heteronuclear chemical shift indirectly from a single one-dimensional proton-observe spectrum and determine it with high accuracy from a extensively-folded two-dimensional proton-observe spectrum.
