帕金森病中脑桥脚核胆碱能神经元的丧失与患者的残疾有关。

Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients.

作者信息

Rinne Juha O, Ma Shuang Yong, Lee Myung Sik, Collan Yrjö, Röyttä Matias

机构信息

Department of Neurology, University of Turku and Turku University Hospital, FIN-20520 Turku, Finland.Turku, Finland.

出版信息

Parkinsonism Relat Disord. 2008 Nov;14(7):553-7. doi: 10.1016/j.parkreldis.2008.01.006. Epub 2008 Mar 10.

DOI:10.1016/j.parkreldis.2008.01.006

PMID:18329941

Abstract

We investigated neuronal number and size in the pars compacta of the pedunculopontine nucleus (PPN) in Parkinson's disease (PD). In PD, the number of Luxol fast blue (LFB) neurons was reduced by 27% from the mean control value (p=0.04) and the cholinergic (choline acetyltransferase, ChAT-positive) neuron number was reduced by 36% (p=0.03). In addition to neuronal loss, the remaining neurons in the PPN in PD were smaller than in controls. The profile area of LFB neurons was reduced by 14% (p=0.009) and that of ChAT-positive neurons by 26% (p=0.001). There was more severe loss of ChAT-positive neurons with a more severe stage of the disease, evaluated by the modified Hoehn and Yahr scale (r=-0.66, p=0.03). The neuron number decreased much more than could be expected on the basis of decrease in cell size alone.

摘要

我们研究了帕金森病（PD）患者中脑脚桥核（PPN）致密部的神经元数量和大小。在帕金森病患者中，鲁尔固蓝（LFB）神经元数量较对照组平均值减少了27%（p = 0.04），胆碱能（胆碱乙酰转移酶，ChAT阳性）神经元数量减少了36%（p = 0.03）。除了神经元丢失外，帕金森病患者PPN中剩余的神经元比对照组的小。LFB神经元的轮廓面积减少了14%（p = 0.009），ChAT阳性神经元的轮廓面积减少了26%（p = 0.001）。根据改良的Hoehn和Yahr量表评估，疾病严重程度越高，ChAT阳性神经元的丢失越严重（r = -0.66，p = 0.03）。神经元数量的减少比仅根据细胞大小的减少所预期的要多得多。