Spitzer Carsten, Barnow Sven, Gau Kay, Freyberger Harald J, Grabe Hans Joergen
Department of Psychiatry and Psychotherapy, Ernst-Moritz-Arndt-University Greifswald am HANSE-Klinikum Stralsund, Stralsund, Germany.
Aust N Z J Psychiatry. 2008 Apr;42(4):335-41. doi: 10.1080/00048670701881538.
There is converging evidence indicating a close association between trauma, particularly childhood trauma, and adult somatization, but studies using both structured interviews and self-report measures to assess childhood adversities in patients with somatization disorder are scarce.
A total of 28 patients (82% women, mean age=41.7+/-10.1 years) meeting DSM-IV criteria for somatization disorder as confirmed by the Structured Clinical Interview for DSM-IV, Axis I (SCID-I) underwent the Structured Trauma Interview (STI) and the Childhood Trauma Questionnaire (CTQ). The comparison group consisted of 28 patients with major depression, but without a lifetime diagnosis of somatization disorder matched for gender and age.
Univariate analyses of both the STI and the CTQ data showed that somatizing patients had been exposed to childhood sexual and physical abuse significantly more often than major depressive disorder (MDD) patients. In logistic regression analysis with somatization disorder as the dependent variable, sexual abuse emerged as the only significant predictor, and the odds of having been sexually abused were ninefold higher in patients with somatization disorders relative to MDD subjects (odds ratio=9.39; 95% confidence interval=1.73-50.96). There were no differences between somatizing and depressed participants with respect to other types of maltreatment.
Childhood sexual abuse is an important factor in the multifactorial aetiopathogenesis of somatization disorder. Diagnostic and therapeutic implications are discussed.
越来越多的证据表明创伤,尤其是童年创伤,与成人躯体化之间存在密切关联,但使用结构化访谈和自我报告测量方法来评估躯体化障碍患者童年逆境的研究较少。
共有28名符合DSM-IV躯体化障碍标准的患者(82%为女性,平均年龄=41.7±10.1岁),经DSM-IV轴I结构化临床访谈(SCID-I)确认后,接受了结构化创伤访谈(STI)和儿童创伤问卷(CTQ)。对照组由28名重度抑郁症患者组成,但无终生躯体化障碍诊断,在性别和年龄上与之匹配。
对STI和CTQ数据的单因素分析均显示,躯体化患者遭受童年性虐待和身体虐待的频率明显高于重度抑郁症(MDD)患者。以躯体化障碍为因变量的逻辑回归分析显示,性虐待是唯一显著的预测因素,躯体化障碍患者遭受性虐待的几率相对于MDD患者高出9倍(优势比=9.39;95%置信区间=1.73-50.96)。在其他类型的虐待方面,躯体化参与者和抑郁参与者之间没有差异。
童年性虐待是躯体化障碍多因素病因发病机制中的一个重要因素。文中讨论了其诊断和治疗意义。