Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.
作者信息
Horne W Seth, Boersma Melissa D, Windsor Matthew A, Gellman Samuel H
机构信息
Department of Chemistry, University of Wisconsin, 1101 University Ave., Madison, WI 53706, USA.
出版信息
Angew Chem Int Ed Engl. 2008;47(15):2853-6. doi: 10.1002/anie.200705315.
Abstract
摘要
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本文引用的文献
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Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL.含α-和β-氨基酸残基的折叠体主链空间探索：开发与Bcl-xL的BH3识别裂隙紧密结合的抗蛋白酶寡聚物。
Chembiochem. 2007 May 25;8(8):903-16. doi: 10.1002/cbic.200600546.
2
Foldamers as versatile frameworks for the design and evolution of function.折叠体作为功能设计与进化的通用框架。
Nat Chem Biol. 2007 May;3(5):252-62. doi: 10.1038/nchembio876.
3
Structural insights into the degradation of Mcl-1 induced by BH3 domains.BH3结构域诱导的Mcl-1降解的结构解析
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. doi: 10.1073/pnas.0701297104. Epub 2007 Mar 27.
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Helix bundle quaternary structure from alpha/beta-peptide foldamers.来自α/β-肽折叠体的螺旋束四级结构。
J Am Chem Soc. 2007 Apr 11;129(14):4178-80. doi: 10.1021/ja070396f. Epub 2007 Mar 16.
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The Bcl-2 apoptotic switch in cancer development and therapy.癌症发展与治疗中的Bcl-2凋亡开关
Oncogene. 2007 Feb 26;26(9):1324-37. doi: 10.1038/sj.onc.1210220.
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7
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.由死亡信号引发的线粒体决定细胞对抗凋亡BCL-2家族成员的依赖性。
Cancer Cell. 2006 May;9(5):351-65. doi: 10.1016/j.ccr.2006.03.027.
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Rational development of beta-peptide inhibitors of human cytomegalovirus entry.人巨细胞病毒进入的β-肽抑制剂的合理开发。
J Biol Chem. 2006 Feb 3;281(5):2661-7. doi: 10.1074/jbc.M508485200. Epub 2005 Nov 7.
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Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.源自氢键替代物的人工α螺旋的增强代谢稳定性和蛋白质结合特性：在Bcl-xL中的应用
Angew Chem Int Ed Engl. 2005 Oct 14;44(40):6525-9. doi: 10.1002/anie.200501603.
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T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo.包含β-氨基酸残基的T细胞决定簇具有蛋白酶抗性，且在体内仍具有免疫原性。
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