Goodman Catherine M, Choi Sungwook, Shandler Scott, DeGrado William F
Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA.
Nat Chem Biol. 2007 May;3(5):252-62. doi: 10.1038/nchembio876.
Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides that fold into well-defined three-dimensional structures. They offer the chemical biologist a broad pallet of building blocks for the construction of molecules that test and extend our understanding of protein folding and function. Foldamers also provide templates for presenting complex arrays of functional groups in virtually unlimited geometrical patterns, thereby presenting attractive opportunities for the design of molecules that bind in a sequence- and structure-specific manner to oligosaccharides, nucleic acids, membranes and proteins. We summarize recent advances and highlight the future applications and challenges of this rapidly expanding field.
折叠体是类似于肽、蛋白质和寡核苷酸的序列特异性寡聚物，它们折叠成明确的三维结构。它们为化学生物学家提供了广泛的构建模块，用于构建测试和拓展我们对蛋白质折叠及功能理解的分子。折叠体还提供模板，以几乎无限的几何模式呈现复杂的官能团阵列，从而为设计以序列和结构特异性方式与寡糖、核酸、膜和蛋白质结合的分子带来了诱人的机会。我们总结了近期的进展，并强调了这个迅速发展的领域的未来应用和挑战。
