Price Thomas S, Jaffee Sara R
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dev Psychol. 2008 Mar;44(2):305-15. doi: 10.1037/0012-1649.44.2.305.
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children's development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do not account for the possibility that children can inherit exposure to family environments (i.e., passive gene-environment correlation). The authors introduce a method to simultaneously estimate the effects of passive gene- environment correlation and gene- environment interaction and use it to investigate the relationship between chaos in the home and verbal ability in a large sample of 4-year-old twins.
经典双胞胎研究为检验有关家庭环境如何影响儿童发展的假设提供了有用的资源,包括基因如何影响对环境影响的敏感性。然而,现有的统计模型没有考虑到儿童可能会遗传对家庭环境的暴露(即被动基因-环境相关性)这一可能性。作者引入了一种方法来同时估计被动基因-环境相关性和基因-环境相互作用的影响,并将其用于调查大量4岁双胞胎样本中家庭混乱与语言能力之间的关系。