Stracke M L, Aznavoorian S A, Beckner M E, Liotta L A, Schiffmann E
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
EXS. 1991;59:147-62. doi: 10.1007/978-3-0348-7494-6_10.
In studying the role of motility in the metastasis of tumor cells, we have described an autocrine motility factor. This agent, which stimulates random motility, probably contributes to the initial dissociation of the cells from the primary tumor mass. Extracellular matrix components, via several different mechanisms, may facilitate the crossing of biological barriers by the cells prior to the entry into the circulation. In locating at new sites, the tumor cells may be induced to exit from the circulation in response to attractants such as IGFs that could emanate from the target organ. These same growth factors could then stimulate cellular proliferation for another metastatic cycle. It is quite probable that detection of AMF may provide a new tool in cancer diagnosis. The complete characterization of AMF may also yield valuable therapeutic approaches: design of low molecular size antagonists of the attractants and antibodies that might be effective therapeutically as well as diagnostically. It seems clear, in any event, that immobilizing the tumor cell may be a crucial step in inhibiting metastasis.
在研究运动性在肿瘤细胞转移中的作用时，我们描述了一种自分泌运动因子。这种刺激随机运动的因子可能促使细胞从原发性肿瘤块中最初解离出来。细胞外基质成分可能通过几种不同机制，在细胞进入循环之前促进其跨越生物屏障。在定位到新位点时，肿瘤细胞可能会响应诸如可能来自靶器官的胰岛素样生长因子（IGFs）等吸引剂而被诱导从循环中逸出。这些相同的生长因子随后可能刺激细胞增殖以进入另一个转移周期。很有可能检测自分泌运动因子（AMF）可为癌症诊断提供一种新工具。对AMF的全面表征也可能产生有价值的治疗方法：设计吸引剂的低分子拮抗剂以及可能在治疗和诊断上均有效的抗体。无论如何，似乎很明显，使肿瘤细胞固定化可能是抑制转移的关键步骤。
