Gregg T A, Leonard A G, Hayden C, Howard K E, Coyle C F
Royal Belfast Hospital for Sick Children, 180 Falls Road, Belfast, Ireland.
Cleft Palate Craniofac J. 2008 Mar;45(2):141-7. doi: 10.1597/06-045.1.
The prevalence of cleft lip and/or palate (CL/P) in Northern Ireland (NI) was last reported for 1980 through 1990. This study was undertaken to update the prevalence of CL/P in NI for the 20-year period 1981 to 2000, to determine the pattern of prevalence, and to report the proportion of different cleft types and sex distribution.
Retrospective, population-based analysis.
PATIENTS/PARTICIPANTS: All live born children with CL/P in NI from 1981 to 2000 were included. A total of 750 cases were identified. Resident births outside NI, stillbirths, abortuses, and children born with atypical orofacial clefts were excluded. Those with syndromes and submucous clefts were included in the study.
The overall prevalence of children born with CL/P within NI for the period 1981 to 2000 was 1.47 per 1000 live births, or 1:682. This was consistent with the findings reported by other U.K. studies. There were no significant changes in the prevalence rates over any 5-year period. No significant seasonality trends were noted. Clefts of the palate only were always in the majority. More boys than girls were affected by cleft lip with or without cleft palate. There was a significant left-sided predilection for unilateral clefting of the lip.
There have been no significant changes in the birth prevalence of children born with CL/P or the distribution or laterality of cleft type in the NI population during the past 20 years.
北爱尔兰唇腭裂（CL/P）的患病率上次报告是针对1980年至1990年期间。本研究旨在更新北爱尔兰1981年至2000年这20年间CL/P的患病率，确定患病率模式，并报告不同腭裂类型的比例及性别分布情况。
基于人群的回顾性分析。
患者/参与者：纳入1981年至2000年在北爱尔兰所有出生时患有CL/P的活产儿童。共确定750例病例。排除北爱尔兰以外地区的常住出生、死产、流产以及患有非典型口腔面部裂的儿童。患有综合征和黏膜下腭裂的儿童纳入研究。
1981年至2000年期间，北爱尔兰出生时患有CL/P的儿童总体患病率为每1000例活产中有1.47例，即1:682。这与英国其他研究报告的结果一致。在任何5年期间患病率均无显著变化。未观察到明显的季节性趋势。仅腭裂始终占多数。唇裂伴或不伴腭裂的患儿中，男孩受累多于女孩。唇裂单侧裂存在显著的左侧偏好。
在过去20年中，北爱尔兰人群中出生时患有CL/P的儿童的出生患病率、腭裂类型的分布或侧别均无显著变化。
