Yuksel O, Kurukahvecioglu O, Ege B, Ekinci O, Aydin A, Poyraz A, Tezel E, Taneri F
Gazi University Faculty of Medicine, Department of Surgery, Ankara, Turkey.
Endocr Regul. 2008 Mar;42(1):29-33.
Pure papillary thyroid carcinoma and the follicular variant papillary thyroid carcinoma are the most common subtypes of papillary thyroid carcinoma. The aim of this study was to investigate the effects of prognostic factors of these two subgroups in our series.
Histopathological type of carcinoma was retrospectively revised in 199 patients who were then divided according to such type. Patients' age and gender as well as the size and multicentricity of tumor, association with Hashimoto's thyroiditis, serum thyroglobulin and anti-thyroglobulin antibodies levels, metastatic lymph node and distant metastases status for both groups were evaluated.
Gender, size, multicentricity of tumor, serum thyroglobulin and anti-thyroglobulin levels were similar in both groups. It was found that, although the tumor size of pure papillary thyroid carcinoma was smaller than that of follicular variant papillary thyroid carcinoma, lymph node metastases occurred more frequently when both subgroups were examined.
The pathological and clinical signs of pure papillary thyroid carcinoma and follicular variant papillary thyroid carcinoma were found similar. According to these results, this study does not support the literature which claims that follicular variant papillary thyroid carcinoma is more aggressive than pure papillary thyroid carcinoma. Moreover, it could be assumed that the number of patients who are diagnosed as pure papillary thyroid carcinoma may be higher when associated with Hashimoto's thyroiditis.
纯乳头状甲状腺癌和滤泡状变异型乳头状甲状腺癌是乳头状甲状腺癌最常见的亚型。本研究旨在探讨这两个亚组的预后因素在我们系列病例中的影响。
对199例患者的癌组织病理类型进行回顾性分析，并根据该类型进行分组。评估两组患者的年龄、性别、肿瘤大小、多中心性、与桥本甲状腺炎的相关性、血清甲状腺球蛋白和抗甲状腺球蛋白抗体水平、转移性淋巴结及远处转移情况。
两组患者的性别、肿瘤大小、多中心性、血清甲状腺球蛋白和抗甲状腺球蛋白水平相似。研究发现，尽管纯乳头状甲状腺癌的肿瘤大小小于滤泡状变异型乳头状甲状腺癌，但在检查这两个亚组时，淋巴结转移更为常见。
纯乳头状甲状腺癌和滤泡状变异型乳头状甲状腺癌的病理和临床征象相似。根据这些结果，本研究不支持文献中关于滤泡状变异型乳头状甲状腺癌比纯乳头状甲状腺癌更具侵袭性的说法。此外，可以推测，与桥本甲状腺炎相关时，被诊断为纯乳头状甲状腺癌的患者数量可能更高。
