Department of Endocrinology and Metabolism, Ankara Ataturk Education and Research Hospital, 06800, Ankara, Turkey.
Endocr Pathol. 2011 Jun;22(2):58-65. doi: 10.1007/s12022-011-9160-0.
Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. Preoperative thyroid functions, thyroid autoantibodies, ultrasonographical features, cytology, and histopathology results of 354 (79.9%) CPTC and 90 (20.3%) FVPTC patients were reviewed retrospectively. Sex distribution, mean age, thyroid autoantibody positivity, and thyroid dysfunctions were similar in two groups. Among 320 patients with preoperative ultrasonography (US) findings, a hypoechoic halo was observed more frequently (p=0.003), and marginal irregularity was observed less commonly (p=0.024) in FVPTC lesions. In CPTC, rate of malignant cytology (p=0.001), and in FVPTC, rate of suspicious cytology (p<0.001) were significantly higher. Histopathologically, mean tumor diameter was markedly higher in FVPTC compared to CPTC (16.89 ± 13.86 vs 10.64 ± 9.70 mm, p<0.001), while capsular invasion and extrathyroidal spread were significantly lower in patients with FVPTC (p=0.018 and p=0.039, respectively). FVPTC tend to have more benign features in US and less malignant results in cytology. Higher tumor size in FVPTC might be explained by the recognition of clinical importance of these lesions after reaching particular sizes due to benign US features.
滤泡型甲状腺乳头状癌（FVPTC）是经典型甲状腺乳头状癌（CPTC）后最常见的甲状腺乳头状癌变异型。本研究旨在比较 CPTC 和 FVPTC 患者的功能状态、超声特征、细胞学结果和组织病理学特征。回顾性分析了 354 例（79.9%）CPTC 和 90 例（20.3%）FVPTC 患者的术前甲状腺功能、甲状腺自身抗体、超声特征、细胞学和组织病理学结果。两组间的性别分布、平均年龄、甲状腺自身抗体阳性率和甲状腺功能障碍相似。在 320 例有术前超声（US）发现的患者中，FVPTC 病变更常表现为低回声晕（p=0.003），边缘不规则性较少见（p=0.024）。在 CPTC 中，恶性细胞学检出率（p=0.001），而在 FVPTC 中，可疑细胞学检出率（p<0.001）明显更高。组织病理学上，FVPTC 的平均肿瘤直径明显高于 CPTC（16.89±13.86 vs 10.64±9.70 mm，p<0.001），而 FVPTC 患者的包膜侵犯和甲状腺外扩散明显较低（p=0.018 和 p=0.039）。FVPTC 在 US 上倾向于具有更多良性特征，而在细胞学上具有更少恶性结果。FVPTC 中较高的肿瘤大小可能是由于良性 US 特征，这些病变在达到特定大小后，由于其临床重要性而被识别。
