Eglen Stephen J, Wong James C T
Cambridge Computational Biology Institute, Department for Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Vis Neurosci. 2008 Mar-Apr;25(2):209-14. doi: 10.1017/S0952523808080176. Epub 2008 Mar 11.
Most types of retinal neurons are spatially positioned in non-random patterns, termed retinal mosaics. Several developmental mechanisms are thought to be important in the formation of these mosaics. Most evidence to date suggests that homotypic constraints within a type of neuron are dominant, and that heterotypic interactions between different types of neuron are rare. In an analysis of macaque H1 and H2 horizontal cell mosaics, Wässle et al. (2000) suggested that the high regularity index of the combined H1 and H2 mosaic might be caused by heterotypic interactions during development. Here we use computer modeling to suggest that the high regularity index of the combined H1 and H2 mosaic is a by-product of the basic constraint that two neurons cannot occupy the same space. The spatial arrangement of type A and type B horizontal cells in cat retina also follow this same principle.
大多数类型的视网膜神经元以非随机模式在空间上定位，称为视网膜镶嵌。几种发育机制被认为在这些镶嵌的形成中很重要。迄今为止的大多数证据表明，一种神经元内的同型限制占主导地位，不同类型神经元之间的异型相互作用很少见。在对猕猴H1和H2水平细胞镶嵌的分析中，瓦塞尔等人（2000年）认为，组合的H1和H2镶嵌的高规则指数可能是发育过程中异型相互作用的结果。在这里，我们使用计算机建模表明，组合的H1和H2镶嵌的高规则指数是两个神经元不能占据同一空间这一基本限制的副产品。猫视网膜中A型和B型水平细胞的空间排列也遵循这一相同原则。
