Yang Chuan-Sheng, Zhang Quan, Guo Zhu-Ming, Zeng Zong-Yuan, Lai Fei-Yun
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
Ai Zheng. 2008 Mar;27(3):311-4.
BACKGROUND & OBJECTIVE: Thyroid carcinoma is rarely occurred in children. Clinicopathologic characteristics, therapy and prognosis of childhood thyroid carcinoma patients are different from those of adult patients, and the treatment of this disease is controversial. This study was to explore the clinicopathologic characteristics, diagnosis and therapy of thyroid carcinoma in children.
Clinical data of 22 children under the age of 14, diagnosed as thyroid carcinoma between Jan. 1980 and Dec. 2000, were reviewed.
According to UICC clinical and histopathologic classification(2002), 19 cases were classified as stageI (2 cases of T1-4N0M0 and 17 cases of T1-4N1M0) and 3 cases as stage II (T1-4N1-4M1). Of the 22 patients, 8 (36.4%) had papillary carcinoma, 8 (36.4%) had follicular carcinoma, 5(22.7%) had mixed papillary-follicular carcinoma, and 1 (4.5%) had medullary carcinoma. All patients had received operation and postoperative thyroxin therapy. Unilateral and bilateral neck dissection had been performed in 12 and 7 patients, respectively; 19 patients had cervical lymph node metastasis. The follow-up period was 6 to 26 years (median, 14.83 years). The 5-and 10-year survival rates were 100% and 95.5%, respectively.
Childhood thyroid carcinomas are mostly differentiated carcinomas, with high frequency of cervical lymph node metastases. The optimal treatment for thyroid carcinoma in children may improve the quality of life and decrease the incidence of complications.
甲状腺癌在儿童中很少见。儿童甲状腺癌患者的临床病理特征、治疗方法及预后与成人患者不同，且该病的治疗存在争议。本研究旨在探讨儿童甲状腺癌的临床病理特征、诊断及治疗方法。
回顾性分析1980年1月至2000年12月期间诊断为甲状腺癌的14岁以下22例儿童的临床资料。
根据UICC（2002年）临床和组织病理学分类，19例为Ⅰ期（2例T1 - 4N0M0和17例T1 - 4N1M0），3例为Ⅱ期（T1 - 4N1 - 4M1）。22例患者中，8例（36.4%）为乳头状癌，8例（36.4%）为滤泡状癌，5例（22.7%）为乳头状 - 滤泡状混合癌，1例（4.5%）为髓样癌。所有患者均接受了手术及术后甲状腺素治疗。12例和7例患者分别进行了单侧和双侧颈淋巴结清扫；19例患者有颈部淋巴结转移。随访时间为6至26年（中位时间为14.83年）。5年和10年生存率分别为100%和95.5%。
儿童甲状腺癌大多为分化型癌，颈部淋巴结转移发生率高。儿童甲状腺癌的最佳治疗方法可能会提高生活质量并降低并发症发生率。
