Huang Xiu-Lan, Cui Guo-Hui, Zhou Ke-Yuan
Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, P. R. China.
Ai Zheng. 2008 Mar;27(3):331-6.
PI3K-Akt signal pathway is an important intracellular signal transduction pathway. It plays important roles in cell apoptosis and survival by affecting the activity of downstream effector molecules, and it is closely associated with the development and progression of human tumors, therefore, PI3K and Akt might be potential targets for tumor therapy. This article reviewed recent progress on the composition, function, regulation and anti-apoptosis of PI3K-Akt signal pathway, and discussed its potential application to tumor gene therapy.
PI3K-Akt信号通路是一条重要的细胞内信号转导通路。它通过影响下游效应分子的活性在细胞凋亡和存活中发挥重要作用，并且与人类肿瘤的发生和发展密切相关，因此，PI3K和Akt可能是肿瘤治疗的潜在靶点。本文综述了PI3K-Akt信号通路的组成、功能、调控及抗凋亡方面的最新研究进展，并探讨了其在肿瘤基因治疗中的潜在应用。
