顺铂功能化磁性纳米颗粒在联合癌症化疗与电磁热疗中的体外分析
In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia.
作者信息
Babincov M, Altanerov V, Altaner C, Bergemann C, Babinec P
机构信息
Department of Nuclear Physics and Biophysics, Comenius University, Bratislava, Slovakia.
出版信息
IEEE Trans Nanobioscience. 2008 Mar;7(1):15-9. doi: 10.1109/TNB.2008.2000145.
A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.
基于用顺二氯二氨合铂（II）（顺铂）功能化的氧化铁磁性纳米颗粒，开发了一种用于联合癌症化疗和热疗的新型平台。研究了该系统的加热和控释能力，并通过处理BP6大鼠肉瘤细胞在体外对该系统进行了测试，我们在该实验中证明了顺铂靶向磁性纳米颗粒的作用与电磁场应用之间的协同作用。
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