Thiesen Burghard, Jordan Andreas
MagForce Nanotechnologies AG, Berlin, Germany.
Int J Hyperthermia. 2008 Sep;24(6):467-74. doi: 10.1080/02656730802104757.
Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio- or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.
磁性流体越来越多地用于临床应用，如药物递送、磁共振成像和磁流体热疗。后者作为一种癌症治疗方法已经发展了几十年，包括将磁性纳米颗粒注入肿瘤，并随后在交变磁场中加热。根据所施加的温度和加热持续时间，这种治疗要么导致直接杀死肿瘤细胞，要么使细胞更容易受到同步放疗或化疗的影响。全球许多研究小组都在这个领域开展工作，但到目前为止只有一种方法在临床试验中得到了测试。在此，我们总结了这些关于磁流体诱导热疗的研究中获得的临床数据。
