Rybski J A, Grogan T M, Aickin M, Gensler H L
Department of Pathology, University of Arizona College of Medicine, Tucson.
J Invest Dermatol. 1991 Nov;97(5):892-7. doi: 10.1111/1523-1747.ep12491637.
The effect of dietary canthaxanthin, retinyl palmitate, or their combination on the tumor-infiltrating T-lymphocyte response (T-TIL) in de novo murine ultraviolet type B irradiation-induced tumors was investigated to elucidate potential mechanisms of action of these compounds. We found that dietary canthaxanthin greatly reduced the number of tumor-infiltrating helper/inducer, suppressor/cytotoxic, and interleukin-2 receptor-positive T lymphocytes and also observed a concomitant statistically significant increase in tumour incidence in canthaxanthin-fed animals. The addition of retinyl palmitate to the canthaxanthin diet ameliorated this negative effect on TIL and the development of skin tumors. We conclude that dietary retinyl palmitate and canthaxanthin can modulate the host T-cell immune response within a growing tumor and may affect tumorigenicity.
研究了日粮中角黄素、视黄醇棕榈酸酯或其组合对新生小鼠紫外线B照射诱导肿瘤中肿瘤浸润性T淋巴细胞反应（T-TIL）的影响，以阐明这些化合物的潜在作用机制。我们发现，日粮中的角黄素大大减少了肿瘤浸润性辅助/诱导性、抑制/细胞毒性和白细胞介素-2受体阳性T淋巴细胞的数量，并且还观察到喂食角黄素的动物肿瘤发生率在统计学上有显著增加。在角黄素日粮中添加视黄醇棕榈酸酯改善了对角黄素诱导淋巴细胞（TIL）和皮肤肿瘤发生的负面影响。我们得出结论，日粮中的视黄醇棕榈酸酯和角黄素可以调节生长肿瘤内的宿主T细胞免疫反应，并可能影响致瘤性。
