Gensler H L, Holladay K
Department of Radiation Oncology, University of Arizona College of Medicine, Tucson 85724.
Cancer Lett. 1990 Mar;49(3):231-6. doi: 10.1016/0304-3835(90)90164-s.
Retinoids and certain carotenoids, e.g., beta-carotene and canthaxanthin, have been found to prevent photocarcinogenesis in mice and also to act as immunoenhancers. The hypothesis that retinoids and carotenoids inhibit photocarcinogenesis by preventing UV induction of immunosuppression predicts that mice treated with these agents before and during periods of UV radiation treatments should be as resistant as unirradiated mice to an antigenic UV-induced tumor. To test this prediction, mice were fed 120 IU of retinyl palmitate per gram of diet, and/or 1% canthaxanthin, before UV irradiation treatments began, and during the entire experiment. After 4.95 x 10(5) Jm-2, delivered over 12 weeks, resistance of mice to antigenic UV-induced tumor implants (UV20) was studied. Dietary supplementation with retinyl palmitate plus canthaxanthin, but not with either agent alone at these doses, prevented the enhanced growth of UV20 in UV irradiated mice.
类视黄醇和某些类胡萝卜素，如β-胡萝卜素和角黄素，已被发现可预防小鼠的光致癌作用，并且还可作为免疫增强剂。类视黄醇和类胡萝卜素通过防止紫外线诱导免疫抑制来抑制光致癌作用这一假说预测，在紫外线辐射治疗之前和期间用这些药物治疗的小鼠，应该与未接受辐射的小鼠一样，对紫外线诱导的抗原性肿瘤具有抗性。为了验证这一预测，在紫外线辐射治疗开始之前以及整个实验过程中，给小鼠喂食每克饲料含120国际单位棕榈酸视黄酯和/或1%角黄素的食物。在12周内给予4.95×10(5) Jm-2的辐射后，研究了小鼠对紫外线诱导的抗原性肿瘤植入物（UV20）的抗性。饮食中补充棕榈酸视黄酯加角黄素，但不是单独使用这两种药物中的任何一种，可防止紫外线照射小鼠中UV20的生长增强。
