Postovsky Sergey, Eran Ayelet, Weyl Ben Arush Myriam
Department of Pediatric Hematology-Oncology, Rambam Health Care Campus and Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel.
Pediatr Neurosurg. 2008;44(3):208-11. doi: 10.1159/000120152. Epub 2008 Mar 11.
A 12-year-old girl was seen in our hospital and diagnosed with diffuse pontine glioma. Treatment with radiotherapy was suggested, but the parents rejected this plan and took the child to another hospital where partial resection of the tumor was performed. The histological diagnosis was anaplastic astrocytoma. Returning to our hospital, the parents agreed to radiotherapy which was given in a total dose of 54 Gy. However, 3 months after completion of radiotherapy, the child developed widespread leptomeningeal dissemination of her disease and died 12 months after the initial diagnosis. Since no effective curative methods of treatment exist for patients with diffuse pontine gliomas and surgical intervention is obsolete in this situation and may facilitate leptomeningeal dissemination of the disease, further innovative methods of treatment are needed to improve the bleak prognosis of these patients.
一名12岁女孩前来我院就诊，被诊断为弥漫性脑桥胶质瘤。建议进行放射治疗，但家长拒绝了该方案，带孩子去了另一家医院，在那里进行了肿瘤部分切除术。组织学诊断为间变性星形细胞瘤。回到我院后，家长同意进行放射治疗，总剂量为54 Gy。然而，放疗结束3个月后，患儿出现了广泛的软脑膜播散，在初次诊断12个月后死亡。由于弥漫性脑桥胶质瘤患者不存在有效的治愈性治疗方法，在这种情况下手术干预已过时且可能促使疾病软脑膜播散，因此需要进一步创新治疗方法来改善这些患者的严峻预后。
