Nakajima M, Katsura K, Hashimoto Y, Terasaki T, Uchino M
Department of Neurology, Kumamoto City Hospital.
Rinsho Shinkeigaku. 2000 Aug;40(8):811-5.
A 49-year-old woman with 6 months history of body weight loss, muscle weakness, and dysarthria, was found with respiratory arrest and resuscitated in the morning of January 1999. An MRI brain scan revealed diffuse swelling and T2/FLAIR high signal intensity with mild Gadolinium enhancement in the lower pons and medulla oblongata. Although the histological diagnosis could not be obtained, glioma (astrocytoma) was suspected. In the morning of July 3rd she presented sweating and cyanosis. Her arterial oxygen saturation was 18%. When we asked her to breathe more, she kept breathing and oxygen saturation was normalized. However, she could not breathe at all when she fell asleep without stimulation. She was kept under respiratory support for 2 months. Her symptoms improved with fluctuating course after 70 Gy of radiation therapy. Ondine curse is one type of sleep apnea syndrome, defined as the selective disturbance of autonomous breathing. Surgical operation and stroke are the reported causes of this syndrome. Brainstem tumor is relatively common cause for children's Ondine curse. On the other hand, it rarely causes adult's Ondine curse as a main symptom.
一名49岁女性，有6个月体重减轻、肌肉无力和构音障碍病史，于1999年1月早晨出现呼吸骤停并接受复苏。脑部MRI扫描显示脑桥下部和延髓弥漫性肿胀，T2/FLAIR高信号强度，钆轻度强化。尽管未能获得组织学诊断，但怀疑为胶质瘤（星形细胞瘤）。7月3日早晨，她出现出汗和发绀。动脉血氧饱和度为18%。当我们要求她加大呼吸力度时，她持续呼吸，血氧饱和度恢复正常。然而，在无刺激入睡时她完全无法呼吸。她接受了2个月的呼吸支持。70Gy放射治疗后，她的症状呈波动过程改善。翁丁氏诅咒是睡眠呼吸暂停综合征的一种类型，定义为自主呼吸的选择性障碍。手术和中风是该综合征的已知病因。脑干肿瘤是儿童翁丁氏诅咒相对常见的病因。另一方面，它很少作为主要症状导致成人的翁丁氏诅咒。
