Kutuk Ozgur, Letai Anthony
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Curr Mol Med. 2008 Mar;8(2):102-18. doi: 10.2174/156652408783769599.
Like many proteins, function and abundance of Bcl-2 family proteins are influenced by posttranslational modifications. These modifications include phosphorylation, proteolytic cleavage, ubiquitination, and proteosomal degradation. These modifications, depending on cellular context and the proteins involved, can result either in a promotion of inhibition of apoptosis. Many of these modifications are governed by the activity of enzymes. As modulation of enzymatic activity can be achieved fairly efficiently using small molecules, understanding the effects of posttranslational modifications may allow for the therapeutic inhibition or promotion of apoptosis.
与许多蛋白质一样，Bcl-2家族蛋白的功能和丰度受翻译后修饰的影响。这些修饰包括磷酸化、蛋白水解切割、泛素化和蛋白酶体降解。根据细胞环境和所涉及的蛋白质，这些修饰既可以促进也可以抑制细胞凋亡。其中许多修饰受酶活性的调控。由于使用小分子可以相当有效地实现酶活性的调节，了解翻译后修饰的作用可能有助于在治疗上抑制或促进细胞凋亡。
