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瑞典1977 - 1991年睾丸固定术的比率。

Rates of orchiopexies in Sweden: 1977-1991.

作者信息

Richiardi L, Vizzini L, Nordenskjöld A, Pettersson A, Akre O

机构信息

Cancer Epidemiology Unit, CeRMS, University of Turin, Turin, Italy.

出版信息

Int J Androl. 2009 Oct;32(5):473-8. doi: 10.1111/j.1365-2605.2008.00881.x. Epub 2008 Mar 10.

Abstract

Cryptorchidism is a known risk factor for testicular cancer and the secular increase in testicular cancer incidence might have been paralleled by a similar increase in cryptorchidism. Data on trends in prevalence of cryptorchidism are however conflicting and decreases have recently been reported. To analyse Swedish trends in rates of orchiopexy, we used the Swedish Hospital Discharge Register to identify all cases of orchiopexy carried out for cryptorchidism between 1977 and 1991, that is, before the era of outpatient orchiopexies in Sweden. Observed trends were analysed in 5-year age groups. The estimated average annual per cent changes (EAPCs) and the years in which the EAPC significantly changed were estimated using Joinpoint Regression. Finally, we estimated the cumulative incidence of orchiopexy by birth cohort. Among boys aged less than 10, the orchiopexy rate started to decrease in the early 1980s. EAPCs were -2.88 (95% confidence interval (CI): -5.48, -0.21) among boys aged 5-9 and -6.63 among those aged 0-4 (95% CI: -8.84, -4.37). Among subjects aged at least 10, the rate decreased over the whole study period. Although the use of orchiopexy rates to measure prevalence of cryptorchidism has limitations, our findings may suggest that cryptorchidism prevalence decreased in Sweden starting from the early 1980s.

摘要

隐睾症是睾丸癌的一个已知风险因素,睾丸癌发病率的长期上升可能伴随着隐睾症的类似增加。然而,关于隐睾症患病率趋势的数据存在矛盾,最近有报道称其有所下降。为了分析瑞典睾丸固定术的发生率趋势,我们使用瑞典医院出院登记册来确定1977年至1991年期间因隐睾症进行的所有睾丸固定术病例,即瑞典门诊睾丸固定术时代之前的病例。在5岁年龄组中分析观察到的趋势。使用Joinpoint回归估计平均每年百分比变化(EAPCs)以及EAPC发生显著变化的年份。最后,我们按出生队列估计睾丸固定术的累积发生率。在10岁以下的男孩中,睾丸固定术率在20世纪80年代初开始下降。5至9岁男孩的EAPCs为-2.88(95%置信区间(CI):-5.48,-0.21),0至4岁男孩为-6.63(95%CI:-8.84,-4.37)。在至少10岁的人群中,该率在整个研究期间都有所下降。尽管使用睾丸固定术率来衡量隐睾症患病率存在局限性,但我们的研究结果可能表明,从20世纪80年代初开始,瑞典的隐睾症患病率有所下降。

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