电生理特征：自闭症谱系障碍中语言障碍神经关联的脑磁图研究
Electrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders.
作者信息
Roberts Timothy P L, Schmidt Gwen L, Egeth Marc, Blaskey Lisa, Rey Michael M, Edgar J Christopher, Levy Susan E
机构信息
Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.
出版信息
Int J Psychophysiol. 2008 May;68(2):149-60. doi: 10.1016/j.ijpsycho.2008.01.012. Epub 2008 Feb 12.
Abstract
While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the spatial and temporal resolution of brain activity offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Specifically, the potential application of MEG is elaborated in autism spectrum disorders (ASD), a devastating disorder with prevalence of 1 in 150. Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD ('electrophysiological signatures') and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders.
摘要
虽然脑磁图（MEG）在癫痫症患儿的评估中越来越有用，但这仅仅反映了该技术的部分临床潜力。除癫痫外，一系列广泛的发育性精神疾病需要MEG所提供的大脑活动的空间和时间分辨率。本文综述了MEG在儿童语言障碍的听觉处理研究中的应用。具体而言，详细阐述了MEG在自闭症谱系障碍（ASD）中的潜在应用，这是一种患病率为1/150的严重疾病。结果表明MEG对检测ASD中听觉处理异常（“电生理特征”）及其临床相关性具有敏感性。这些发现为发育性神经精神疾病的综合评估带来了希望。
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