Minster Ryan L, DeKosky Steven T, Kamboh M Ilyas
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Neurobiol Aging. 2009 Nov;30(11):1890-1. doi: 10.1016/j.neurobiolaging.2008.01.006. Epub 2008 Mar 11.
Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively. We examined the most significant two single-nucleotide polymorphisms (SNPs) in DAPK1 in a large case-control cohort of late-onset subjects and matched controls and one of the most significant SNPs in ABCA2 in a small set of early-onset subjects as well. We did not detect associations with AD for any variation.
最近有报道称，DAPK1和ABCA2基因的遗传变异分别与晚发型和早发型阿尔茨海默病（AD）相关。我们在一个大型晚发型病例对照队列及其匹配对照中检测了DAPK1中最显著的两个单核苷酸多态性（SNP），并在一小部分早发型受试者中检测了ABCA2中最显著的一个SNP。我们未检测到任何变异与AD有关联。
