Kuperman Yael, Chen Alon
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
Trends Endocrinol Metab. 2008 May-Jun;19(4):122-9. doi: 10.1016/j.tem.2007.12.002. Epub 2008 Mar 11.
The effects of stress on energy balance and the involvement of the neuropeptide corticotropin releasing factor in modulating the anorexia of stress and sympathetic nervous system tone are well recognized. Currently, studies centered on the roles of the more recently described members of this family of ligands, the urocortins, and their preferred receptor, the corticotropin releasing factor type 2 receptor, suggest that they are important modulators of centrally controlled metabolic functions. In addition, urocortins also regulate fuel utilization in the periphery by acting locally within key metabolic tissues through autocrine and/or paracrine mechanisms. Recent findings have demonstrated that urocortin 2 and urocortin 3, by acting through their specific receptor in peripheral tissues, are novel modulators of glucose homeostasis and metabolic functions.
压力对能量平衡的影响以及神经肽促肾上腺皮质激素释放因子在调节应激性厌食和交感神经系统张力中的作用已得到充分认识。目前，以该配体家族中最新描述的成员尿皮质素及其首选受体促肾上腺皮质激素释放因子2型受体的作用为中心的研究表明，它们是中枢控制代谢功能的重要调节因子。此外，尿皮质素还通过自分泌和/或旁分泌机制在关键代谢组织内局部发挥作用，从而在外周调节燃料利用。最近的研究结果表明，尿皮质素2和尿皮质素3通过其在外周组织中的特异性受体发挥作用，是葡萄糖稳态和代谢功能的新型调节因子。
