Adamec Robert, Shallow Tanya, Burton Paul
Department of Psychology, Memorial University, St. John's, NFLD, Canada A1B 3X9.
Behav Brain Res. 2005 Apr 15;159(1):73-88. doi: 10.1016/j.bbr.2004.10.004.
Effects of kindling of right and left basolateral amygdala (BLA) on plus maze anxiety was studied. Using a validated retest paradigm, it was possible to retest rats in the plus maze without increasing anxiety on retest. This permitted determining prekindling baseline levels of plus maze anxiety. Right BLA kindling of high baseline anxiety rats was anxiolytic one week after kindling. Right BLA kindling of low baseline anxiety rats was anxiogenic. In addition, left BLA kindling was either anxiogenic or without effect on plus maze anxiety, depending on baseline anxiety. Effects in left BLA differ from previous work showing anxiolytic effects of left BLA kindling. The discrepancy could be explained in part by prekindling baseline anxiety. These findings require modification of the previous conclusion that left hemisphere (left BLA) kindling is anxiolytic and right BLA kindling is anxiogenic in the plus maze. Rather the hemisphere difference may be due to an interaction between baseline anxiety level and kindling. If true, anxious disposition in rodents may interact with amygdala kindling to change amygdala function differently. Kindling and baseline anxiety effects on other behaviors (such as risk assessment and resistance to capture) are also described. Present data in the light of past studies suggest both premorbid anxiety state and location of the kindling electrode contribute to the effects of kindling on behavior.
研究了右侧和左侧基底外侧杏仁核（BLA）点燃对高架迷宫焦虑的影响。使用经过验证的重测范式，可以在高架迷宫中对大鼠进行重测，而不会在重测时增加焦虑。这使得能够确定点燃前高架迷宫焦虑的基线水平。高基线焦虑大鼠右侧BLA点燃在点燃后一周具有抗焦虑作用。低基线焦虑大鼠右侧BLA点燃具有致焦虑作用。此外，左侧BLA点燃根据基线焦虑情况要么具有致焦虑作用，要么对高架迷宫焦虑没有影响。左侧BLA的作用与之前显示左侧BLA点燃具有抗焦虑作用的研究不同。这种差异部分可以通过点燃前的基线焦虑来解释。这些发现需要修正之前的结论，即在高架迷宫中左半球（左侧BLA）点燃具有抗焦虑作用，而右侧BLA点燃具有致焦虑作用。相反，半球差异可能是由于基线焦虑水平和点燃之间的相互作用。如果是这样，啮齿动物的焦虑倾向可能与杏仁核点燃相互作用，以不同方式改变杏仁核功能。还描述了点燃和基线焦虑对其他行为（如风险评估和被捕抗性）的影响。根据过去的研究，目前的数据表明病前焦虑状态和点燃电极的位置都有助于点燃对行为的影响。
