Joung Yoon Ki, Choi Jong Hoon, Bae Jin Woo, Park Ki Dong
Department of Molecular Science and Technology, Ajou University, Yeoungtong, Suwon, Republic of Korea.
Acta Biomater. 2008 Jul;4(4):960-6. doi: 10.1016/j.actbio.2008.02.008. Epub 2008 Mar 3.
A new hyper-branched surface in which three species of architectures were constructed as stem chain, branched stem and twig chain-grafted branched chain of poly(poly(ethylene glycol)methacrylate) (poly(PEGMA)) by photo-polymerization using dithiocarbamyl group (DC) as iniferter was prepared and characterized. For these surfaces, radical copolymerization of styrene and an iniferter-activated chain that was previously synthesized was performed for using as base materials for surface coating. On a DC-activated surface, hyper-branched poly(PEGMA) was introduced by photo-polymerization and dithiocarbamylation. All modified surfaces were analyzed by X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. Our results demonstrated that a highly hyper-branched graft architecture of poly(PEGMA) can be constructed on PU surface by photo-polymerization using dithiocarbamyl group as iniferter, in which first, second and third generation gave stem chain, branched chain and twig chain of poly(PEGMA), respectively. Our hyper-branched surfaces could be regulated by photo-irradiation time and might be controlled by feed amounts or other reaction conditions. This highly dense architecture of PEG chain with hydrophilicity and chain mobility, grafted on surface, is expected to be effectively utilized in bio-implantable substrates or micro- or nano-patterned surfaces for immobilization of bioactive molecules in biomedical fields.
制备并表征了一种新型超支化表面，该表面通过使用二硫代氨基甲酰基（DC）作为引发转移终止剂，通过光聚合构建了三种结构的聚（聚乙二醇甲基丙烯酸酯）（聚（PEGMA））作为主链、支化主链和树枝状链接枝支链。对于这些表面，进行了苯乙烯与先前合成的引发转移终止剂活化链的自由基共聚反应，以用作表面涂层的基材。在DC活化的表面上，通过光聚合和二硫代氨基甲酰化引入了超支化聚（PEGMA）。所有改性表面均通过X射线光电子能谱（XPS）和水接触角测量进行分析。我们的结果表明，使用二硫代氨基甲酰基作为引发转移终止剂，通过光聚合可以在聚氨酯表面构建高度超支化的聚（PEGMA）接枝结构，其中第一代、第二代和第三代分别给出了聚（PEGMA）的主链、支链和树枝状链。我们的超支化表面可以通过光照射时间进行调节，也可能受进料量或其他反应条件的控制。这种接枝在表面上的具有亲水性和链流动性的高度致密的PEG链结构，有望在生物医学领域的生物可植入基材或微纳图案化表面中有效用于固定生物活性分子。
