Ray J G, Goodman J, O'Mahoney P R A, Mamdani M M, Jiang D
Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada.
QJM. 2008 Jun;101(6):475-7. doi: 10.1093/qjmed/hcn031. Epub 2008 Mar 12.
Vitamin B12 deficiency may be an independent risk factor for neural tube defects (NTD). We determined the prevalence of biochemical B12 deficiency (<125 pmol/l) among 10 622 Ontarian women aged 15-46 years who underwent concomitant testing of serum bhCG and B12 9 years after the implementation of Canadian folic acid flour fortification. The overall prevalence of biochemical B12 deficiency was 7.4%. Relative to non-pregnant women, the adjusted odds ratio (95% confidence interval) of biochemical B12 deficiency was 0.78 (0.60-1.0) among women pregnant 28 days gestation or less and was 1.4 (1.1-1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered.
维生素B12缺乏可能是神经管缺陷（NTD）的一个独立危险因素。我们测定了10622名年龄在15至46岁之间的安大略省女性中生化性B12缺乏（<125 pmol/l）的患病率，这些女性在加拿大实施叶酸强化面粉9年后同时进行了血清人绒毛膜促性腺激素（bhCG）和B12检测。生化性B12缺乏的总体患病率为7.4%。相对于未怀孕女性，妊娠28天及以内的孕妇生化性B12缺乏的校正比值比（95%置信区间）为0.78（0.60 - 1.0），妊娠28天后为1.4（1.1 - 1.8）。约每20名女性中就有1名在孕早期可能缺乏B12。应考虑其对母婴健康的影响，包括可预防的神经管缺陷。
