Whitty Marie, Kelly Fionnuala, Ramsay Louis
St Raphael's Hospital, Celbridge, Co. Kildare, Ireland.
J Intellect Disabil. 2008 Mar;12(1):41-8. doi: 10.1177/1744629507086607.
This is a case report of a gentleman with an intellectual impairment who presented with both hereditary spastic paraplegia (HSD) and bipolar affective disorder (BPAD), a combination that has not yet been described in the professional literature. A limited number of articles have suggested an association between HSP and an organic personality disorder. We describe the case of a gentleman who was diagnosed with BPAD in his early adult life and displayed neurological symptoms of HSP at around the same time. Diagnosis of both HSP and BPAD can be difficult and is further compounded by an intellectual impairment. Treatment options may be limited by the propensity of many psychotropic medications to cause movement disorders and thus worsening neurological symptoms.
这是一篇关于一位患有智力障碍的男性的病例报告，该患者同时患有遗传性痉挛性截瘫（HSD）和双相情感障碍（BPAD），这种组合在专业文献中尚未有过描述。少数文章曾提出HSP与器质性人格障碍之间存在关联。我们描述了一位男性的病例，他在成年早期被诊断出患有BPAD，大约在同一时间出现了HSP的神经症状。HSP和BPAD的诊断都可能很困难，而智力障碍更是加剧了这种情况。许多精神药物容易引发运动障碍，进而加重神经症状，这可能会限制治疗选择。
