Nayak Raghavendra B, Bhogale Govind S, Patil Nanasaheb M, Pandurangi Aditya A
Department of Psychiatry, Jawaharlal Nehru Medical College, KLE University, Belgaum, Karnataka, India.
J Neurosci Rural Pract. 2011 Jul;2(2):190-2. doi: 10.4103/0976-3147.83592.
Hereditary spastic paraparesis (HSP) is an inherited group of neurological disorders with progressive lower limb spasticity. HSP can be clinically grouped into pure and complicated forms. Pure HSP is one without any associated neurological/psychiatric comorbidity. Depression is the most common psychiatric comorbidity. Presence of mania or bipolar affective illness with HSP is a rare phenomenon. We report a case of a 17-year-old boy who presented with classical features of HSP with complaints of excessive happiness, irritability, increased self-esteem and decreased sleep since 1 month. The patient also had complex partial seizure ever since he had features of HSP. The patient's father and younger sister suffer from pure HSP. The patient was diagnosed to have first episode mania with complicated HSP. The details of treatment and possible neurobiology are discussed in this case report.
遗传性痉挛性截瘫（HSP）是一组具有进行性下肢痉挛的遗传性神经疾病。HSP在临床上可分为单纯型和复杂型。单纯型HSP是指不伴有任何相关神经/精神合并症的类型。抑郁症是最常见的精神合并症。HSP合并躁狂或双相情感障碍是一种罕见现象。我们报告一例17岁男孩，自1个月前出现HSP的典型特征，并伴有过度快乐、易怒、自尊增强和睡眠减少的主诉。该患者自出现HSP特征以来还患有复杂部分性发作。患者的父亲和妹妹患有单纯型HSP。该患者被诊断为首发躁狂症合并复杂型HSP。本病例报告讨论了治疗细节及可能的神经生物学机制。
