Yoon In-Kyu, Cox Josephine, Zhou Yaling, Lukes Yvonne, Reinhardt Brian, Valencia-Micolta Anais, Wortmann Glenn
Allergy and Immunology Division, Department of Clinical Investigation, and Infectious Disease Division, Walter Reed Army Medical Center, Washington, District of Columbia 20307-5100, USA.
Am J Trop Med Hyg. 2008 Mar;78(3):402-5.
Sodium stibogluconate has been associated with the reactivation of varicella zoster virus (VZV) in otherwise healthy adults who receive the drug as treatment for cutaneous leishmaniasis. Ten patients receiving daily sodium stibogluconate underwent phlebotomy at baseline and at day 10. Flow cytometry-based immunophenotyping, VZV-specific IgG levels, and lymphocyte proliferative responses and intracellular cytokine secretion to VZV, cytomegalovirus, tetanus toxoid, superantigen, and mitogens were performed at both time points. The absolute number of total leukocytes, total lymphocytes, and lymphocyte subsets decreased overall without predilection for any particular subset of lymphocytes, such that the percentage of the total lymphocyte population for each lymphocyte subset did not change significantly (except for a marginal increase in percentage of cytotoxic T cells). Antibodies to VZV were measured in seven patients before and after treatment, and did not change. Lymphocyte proliferative responses to VZV and other antigens and mitogens did not change from baseline. The mechanism for the increased rate of VZV reactivation after treatment with sodium stibogluconate remains undefined.
葡萄糖酸锑钠与在接受该药治疗皮肤利什曼病的原本健康的成年人中水痘带状疱疹病毒（VZV）再激活有关。10名每日接受葡萄糖酸锑钠治疗的患者在基线期和第10天接受了静脉穿刺采血。在两个时间点均进行了基于流式细胞术的免疫表型分析、VZV特异性IgG水平检测，以及针对VZV、巨细胞病毒、破伤风类毒素、超抗原和丝裂原的淋巴细胞增殖反应及细胞内细胞因子分泌检测。总体而言，总白细胞、总淋巴细胞及淋巴细胞亚群的绝对数量均减少，且无特定淋巴细胞亚群的偏好，因此每个淋巴细胞亚群在总淋巴细胞群体中的百分比没有显著变化（除细胞毒性T细胞百分比略有增加外）。在7名患者治疗前后检测了VZV抗体，抗体水平未发生变化。对VZV及其他抗原和丝裂原的淋巴细胞增殖反应与基线相比未发生变化。葡萄糖酸锑钠治疗后VZV再激活率增加的机制仍不明确。
