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在用锑化合物治疗皮肤利什曼病期间或之后立即发生的水痘带状疱疹病毒再激活。

Varicella zoster virus reactivation during or immediately following treatment of tegumentary leishmaniasis with antimony compounds.

作者信息

Barros Andrea Barbieri, Rodrigues Alex Miranda, Batista Mariane Pereira, Munhoz Junior Sidney, Hueb Marcia, Fontes Cor Jesus

机构信息

Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Cuiabá, MT, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2014 Jul;109(4):499-501. doi: 10.1590/0074-0276130563. Epub 2014 Jul 3.

DOI:10.1590/0074-0276130563
PMID:25004145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4155856/
Abstract

Antimony compounds are the cornerstone treatments for tegumentary leishmaniasis. The reactivation of herpes virus is a side effect described in few reports. We conducted an observational study to describe the incidence of herpes zoster reactivation during treatment with antimony compounds. The global incidence of herpes zoster is approximately 2.5 cases per 1,000 persons per month (or 30 cases per 1,000 persons per year). The estimated incidence of herpes zoster in patients undergoing antimony therapy is higher than previously reported.

摘要

锑化合物是皮肤利什曼病的基础治疗药物。疱疹病毒再激活是少数报告中描述的一种副作用。我们进行了一项观察性研究,以描述锑化合物治疗期间带状疱疹再激活的发生率。带状疱疹的全球发病率约为每月每1000人中有2.5例(或每年每1000人中有30例)。接受锑治疗的患者中带状疱疹的估计发病率高于先前报告的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a42b/4155856/f0d263cb012b/0074-0276-mioc-109-4-0499-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a42b/4155856/f0d263cb012b/0074-0276-mioc-109-4-0499-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a42b/4155856/f0d263cb012b/0074-0276-mioc-109-4-0499-gf01.jpg

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本文引用的文献

1
Leishmaniasis worldwide and global estimates of its incidence.全球利什曼病及其发病率的全球估计。
PLoS One. 2012;7(5):e35671. doi: 10.1371/journal.pone.0035671. Epub 2012 May 31.
2
Viral infection and reactivation in autoimmune disease.自身免疫性疾病中的病毒感染与再激活
Arthritis Rheum. 2008 Oct;58(10):2949-57. doi: 10.1002/art.23883.
3
Varicella zoster virus--specific immune response after treatment with sodium stibogluconate for cutaneous leishmaniasis.葡萄糖酸锑钠治疗皮肤利什曼病后水痘带状疱疹病毒特异性免疫反应
Am J Trop Med Hyg. 2008 Mar;78(3):402-5.
4
Varicella zoster virus meningitis complicating sodium stibogluconate treatment for cutaneous leishmaniasis.葡萄糖酸锑钠治疗皮肤利什曼病并发水痘带状疱疹病毒脑膜炎
Am J Trop Med Hyg. 2006 Apr;74(4):591-2.
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Herpes zoster and lymphopenia associated with sodium stibogluconate therapy for cutaneous leishmaniasis.葡萄糖酸锑钠治疗皮肤利什曼病相关的带状疱疹和淋巴细胞减少症。
Clin Infect Dis. 1998 Sep;27(3):509-12. doi: 10.1086/514689.
8
A comparison of three dosage regimens of sodium stibogluconate in the treatment of visceral leishmaniasis in Kenya.肯尼亚三种葡糖酸锑钠给药方案治疗内脏利什曼病的比较。
J Infect Dis. 1983 Jul;148(1):148-55. doi: 10.1093/infdis/148.1.148.
9
[Herpes zoster as a result of the toxic effect of antimony compounds on the organism].[锑化合物对机体产生毒性作用导致的带状疱疹]
Med Parazitol (Mosk). 1966 Sep-Oct;35(5):600-1.
10
Efficacy and toxicity of sodium stibogluconate for mucosal leishmaniasis.葡萄糖酸锑钠治疗黏膜利什曼病的疗效与毒性
Ann Intern Med. 1990 Dec 15;113(12):934-40. doi: 10.7326/0003-4819-113-12-934.