Bolton Eleanor M, Bradley J Andrew, Pettigrew Gavin J
NIHR Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Transplantation. 2008 Mar 15;85(5):667-9. doi: 10.1097/TP.0b013e3181664db3.
Donor dendritic cells are potent but short-lived stimulators of early transplant rejection, and recipient antigen presenting cells presenting donor major histocompatibility complex peptides sustain immunoreactivity and contribute to chronic rejection. We briefly consider how CD4 T cells that recognize allopeptide can provide help for effector and regulatory responses and highlight the implications for promoting graft survival.
