Cozzio Antonio, French Lars E
Department of Dermatology, Zurich University Hospital, Zurich, Swizerland.
J Invest Dermatol. 2008 Apr;128(4):771-3. doi: 10.1038/jid.2008.49.
The distinction between certain benign cutaneous lymphocytic infiltrates and cutaneous T-cell lymphoma (CTCL) can be a challenging problem in clinical practice. An imperfect but useful tool in this circumstance is the analysis of T-cell clonality or monoclonality by assessing T-cell receptor (TCR) gene rearrangements. "Monoclonality" describes the origin of a specific human malignant tumor from one single cell from which the entire tumor is derived. The term is used to describe the early steps in tumorigenesis; in later stages of tumor growth and progression, monoclonal tumor cells may acquire a mutator phenotype, rendering the genome unstable. The resulting genetic heterogeneity may ultimately lead to subclones in the formerly monoclonal population of tumor cells.
在临床实践中，区分某些良性皮肤淋巴细胞浸润与皮肤T细胞淋巴瘤（CTCL）可能是一个具有挑战性的问题。在这种情况下，一个虽不完美但有用的工具是通过评估T细胞受体（TCR）基因重排来分析T细胞克隆性或单克隆性。“单克隆性”描述了特定人类恶性肿瘤起源于单个细胞，整个肿瘤均由该细胞衍生而来。该术语用于描述肿瘤发生的早期阶段；在肿瘤生长和进展的后期，单克隆肿瘤细胞可能获得突变体表型，使基因组不稳定。由此产生的遗传异质性最终可能导致先前单克隆性肿瘤细胞群体中出现亚克隆。
