Segaert Siegfried
Department of Dermatology, University Hospital Leuven, Belgium.
J Invest Dermatol. 2008 Apr;128(4):773-5. doi: 10.1038/jid.2008.35.
1,25-Dihydroxyvitamin D(3), the active form of vitamin D, is a major regulator of the expression of the cationic antimicrobial peptide cathelicidin, not only in monocytes but also in epidermal keratinocytes. The involvement of cathelicidin in wound healing and skin diseases as diverse as psoriasis, rosacea, and atopic dermatitis may create new opportunities for the use of vitamin D in dermatology.
1,25-二羟维生素D(3)是维生素D的活性形式，不仅是单核细胞中阳离子抗菌肽cathelicidin表达的主要调节因子，也是表皮角质形成细胞中该因子表达的主要调节因子。Cathelicidin参与伤口愈合以及银屑病、玫瑰痤疮和特应性皮炎等多种皮肤病的过程，这可能为维生素D在皮肤病学中的应用创造新机会。
