Jain Rakesh K
Edwin L. Steele Laboratory for Tumour Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, Massachusetts 02114, USA.
Nat Rev Cancer. 2008 Apr;8(4):309-16. doi: 10.1038/nrc2346.
The importance of multidisciplinary translational clinical trials is obvious; however, making them work is complex and challenging. Here I present an argument for designing and implementing multidisciplinary mechanistic trials and present the lessons our team at the Massachusetts General Hospital Cancer Center has learned from two such trials in cancer patients with locally advanced rectal carcinomas and recurrent glioblastomas.
多学科转化性临床试验的重要性不言而喻；然而，要使其发挥作用却复杂且具有挑战性。在此，我提出设计和实施多学科机制性试验的理由，并介绍我们麻省总医院癌症中心团队从针对局部晚期直肠癌和复发性胶质母细胞瘤患者的两项此类试验中所学到的经验教训。
