Yiu K-H, Tse H-F
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
J Hum Hypertens. 2008 Jun;22(6):380-8. doi: 10.1038/jhh.2008.10. Epub 2008 Mar 13.
Hypertension is commonly associated with cardiac arrhythmias in patients with and without concomitant cardiovascular disease. Experimental and epidemiological studies have demonstrated potential links between hypertension and atrial and ventricular arrhythmias, although the underlying pathophysiological mechanism remains unclear. Nonetheless, the importance of hypertension as a cause of atrial and ventricular arrhythmias is not well recognized. In particular, the occurrence of left ventricular hypertrophy is a strong predictor for the development of AF, ventricular ectopy and sudden cardiac death. Recent prospective clinical trials reveal that antihypertensive therapy may delay or prevent the occurrence of cardiac arrhythmias and sudden cardiac death in patients with hypertension. Although antihypertensive agents that block the renin-angiotensin-aldosterone system appear to protect against cardiac arrhythmias, this needs to be confirmed by current ongoing clinical trials.
高血压在伴有或不伴有心血管疾病的患者中通常与心律失常相关。实验和流行病学研究已证明高血压与房性和室性心律失常之间存在潜在联系，尽管潜在的病理生理机制仍不清楚。然而，高血压作为房性和室性心律失常病因的重要性尚未得到充分认识。特别是，左心室肥厚的发生是房颤、室性早搏和心源性猝死发生的有力预测指标。最近的前瞻性临床试验表明，抗高血压治疗可能会延迟或预防高血压患者心律失常和心源性猝死的发生。尽管阻断肾素-血管紧张素-醛固酮系统的抗高血压药物似乎能预防心律失常，但这需要当前正在进行的临床试验予以证实。
